We have no knowledge of any Berryman Products fuel additives harming the Prius fuel bladders. However, if you’re concerned about compatibility, you might consider using only fuel additives in plastic bottles, such as our B-12 Chemtool Injector Cleaner (part #1112) or Super Concentrated Valve & Injector Cleaner (part #3012). These two products do not have the same aggressive solvents that our additives in metal cans have; however, they have other active solvents in addition to high-performance detergents.